Respiratory syncytial virus (RSV) is a virus that infects nearly all Americans by the age of two. Though the severity of an RSV infection can vary by age group, it’s the leading cause of hospitalizations for infants.
Seasonal patterns for RSV have historically been consistent, but the COVID-19 pandemic disrupted the circulation of RSV, significantly increasing in prevalence and severity of recent infections. To reduce the burden of RSV-related medical visits and hospitalizations, and protect our nation’s most vulnerable populations, researchers are prioritizing rapid advancement of preventive therapies.
While there is no specific treatment for RSV at this time, leading vaccine manufacturers have made significant progress in the development of antivirals and vaccines to help providers across the country combat the growing threat of RSV.
RSV and Its Symptoms
RSV is a highly contagious virus that can lead to serious respiratory illness, especially in infants. In a typical year, RSV leads to two million outpatient visits, 120,000 hospitalizations, and several thousand deaths, but the most recent virus seasons have been anything but normal. Like most respiratory viruses, RSV spreads when droplets from a cough, sneeze, or infected surface get into the mouth, nose, or eyes. Initial RSV symptoms mimic those of a cold or the flu, but worsen as the infection gets more severe. In infants less than six months old, the only symptoms of RSV may be irritability, decreased activity, decreased appetite, and difficulty breathing. Early symptoms of RSV in children and older adults include runny nose, decrease in appetite, and cough, which may progress to wheezing or difficulty breathing a few days into the illness.
High-Risk Populations for Severe RSV
According to the CDC, most patients infected with a mild case of RSV recover in a week or two, but certain populations are more likely to develop a severe RSV infection, which can lead to hospitalization or intensive care. Each year, approximately 58,000-80,000 children younger than five years old are hospitalized for RSV. A severe RSV infection can lead to serious conditions like bronchiolitis and pneumonia. Those at greatest risk include premature infants, infants younger than six months old, children younger than two years old with chronic lung disease or congenital heart disease, children with weakened immune systems, and children who have neuromuscular disorders.
While RSV infections are most common among young children, adults over 65 are also considered high risk. Each year, approximately 60,000-160,000 older adults are hospitalized and 6,000-10,000 die from an RSV-related illness.
A Rare RSV Surge
During the peak of the COVID-19 pandemic, people were quarantining and masking; and as a result, cases of respiratory infections like flu and RSV remained low. In contrast, the 2022-2023 virus season saw RSV cases start in the spring, much earlier than normal, and a 60% increase in infection rates from 2021. This unprecedented surge threatens an onset of a “tripledemic”—the a combination of flu, RSV, and COVID-19.
RSV Protection on the Horizon
Despite these growing risks—there is good news. In January, the U.S. Food and Drug Administration (FDA) accepted nirsevimab antibody application as the first protective option against RSV disease for all infants. Additionally, we can expect FDA approval for the first RSV vaccine as early as summer 2023. Once RSV therapies are approved, Atlantic Health Partners is committed to making these vaccinations available to our members to help support equitable access and ensure all high-risk populations are protected against this contagious and dangerous virus.